5-HTP (5-hydroxytryptophan) has studies showing its effectiveness and safety for depression. 5-HTP is the precursor of serotonin, which is the neurotransmitter in the brain that are hypothesized to be deficient in depression.
Tryptophan ➨ 5-HTP ➨ Serotonin
The serotonin hypothesis of depression states that depression is caused by a deficiency of serotonin in the synapses of the neurons of the brain circuits that modulate depression. The popular SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants are often utilized to treat depression, where they increase synaptic serotonin by inhibiting the reuptake of serotonin presynaptically. However, SSRIs come with significant side effects and require a doctor’s prescription. There is a natural alternative which has studies showing its effectiveness and safety in the treatment of depression
5-HTP is an aromatic amino acid that is produced by the body from tryptophan, and is involved with the production of serotonin. Commercially, 5-HTP is produced by extraction from Griffonia simplicifolia seeds. Thus, oral 5-HTP is a natural dietary supplement, and has been used in the treatment of depression for the past 40 years.
When taken orally, 5-HTP increases serotonin in the synapses, as 5-HTP is a precursor of serotonin. There are multiple studies showing that 5-HTP is effective and safe for depression. There are 27 clinical studies of 5-HTP for depression, of which the majority of studies showed that 5-HTP was effective and safe for depression (Iovieno et al., 2011). The majority of the studies administered between 200mg to 300mg per day of 5-HTP. At this dosing range, 5-HTP is well tolerated, and the most common side effects include nausea, vomiting, and diarrhea (Iovieno et al., 2011).
The reason for the lack of use of 5-HTP in the treatment of depression is because of the focus and huge marketing blitz of the SSRIs, where the SSRIs have dominated the treatment of depression since the late 1980’s. However, with the ongoing backlash against the SSRIs and its numerous side effects, people are seeking natural and safer alternative treatments for the treatment of depression, such as the natural dietary supplement 5-HTP.
Fortunately, there is a natural 5-HTP formulation that can treat depression safely: the all-new KalmPro Mood Support. 100% satisfaction guaranteed, or your money back.
photo credit: By RicHard-59 based on Trp-5ht-pathway.png by Likeitsmyjob – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=18487902
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cannabis products helps with anxiety
For some people, over the short term, maybe. But for other people, it can trigger and induce anxiety, especially long-term use.
Great! Thanks for explaining depression here with us. The chemical composition in the body that causes depression should be understood pretty well. Depression can be quite difficult to handle. The above information was actually great. Keep sharing this more and more! It would be nice if you provide some more information on this!
Thanks for the feedback, and thanks for visiting!
Hello Doctor, is it true that 5htp can cause EMS? (eosinophilia-myalgia syndrome)
EMS is mainly associated with tryptophan supplements, and not with 5-HTP. Try this tested brand: https://www.kalmpro.com/kalmpro_mood.html
Is it true that 5 HTP depletes dopamine? If true, how do we maintain the balance of serotonin and dopamine?
There is some evidence to suggest that 5-HTP (5-Hydroxytryptophan), a precursor to serotonin, may have an impact on dopamine levels, but the relationship between the two neurotransmitters is complex and not fully understood. Here’s some information on this topic:
1. **5-HTP and Serotonin**: 5-HTP is a naturally occurring amino acid that is converted in the body into serotonin, a neurotransmitter that plays a role in regulating mood, sleep, and appetite. Many people take 5-HTP supplements to boost serotonin levels and potentially alleviate symptoms of conditions like depression and anxiety.
2. **Dopamine and Serotonin**: Serotonin and dopamine are two different neurotransmitters that can influence mood and other aspects of brain function. While they have distinct roles, there is some interplay between them. Changes in one neurotransmitter can affect the other, and an imbalance in either can lead to various mental health issues.
3. **5-HTP and Dopamine**: Some research has suggested that increasing serotonin levels, such as through the use of 5-HTP supplements, might indirectly affect dopamine levels. The exact mechanisms are not well-established, but it’s thought that increased serotonin can lead to changes in the synthesis and release of dopamine in certain brain regions.
4. **Balancing Serotonin and Dopamine**: Maintaining a balance between serotonin and dopamine is crucial for overall mental well-being. Here are some general tips to help support this balance:
– **Healthy Lifestyle**: Engage in regular physical activity, get adequate sleep, and maintain a balanced diet. These factors can positively influence both serotonin and dopamine levels.
– **Nutrition**: Ensure that your diet includes the necessary nutrients for neurotransmitter production, such as amino acids (like tryptophan for serotonin and tyrosine for dopamine). Eating a variety of whole foods can help provide these nutrients.
– **Consult a Healthcare Professional**: If you’re considering supplements like 5-HTP or other interventions to support your mental health, it’s essential to consult with a healthcare professional. They can assess your specific needs and provide guidance tailored to your situation.
– **Medication**: In some cases, individuals with severe imbalances may benefit from prescription medications that target serotonin or dopamine levels. These should only be used under the supervision of a healthcare provider.
It’s important to note that individual responses to supplements and lifestyle changes can vary widely. What works for one person may not work the same way for another. If you have concerns about the balance of serotonin and dopamine in your system or are considering any supplements, consult a healthcare provider or a mental health professional who can provide personalized guidance based on your specific needs and circumstances. They can help you develop a comprehensive approach to maintaining mental well-being.