Yes, you can take KalmPro with Zoloft (sertraline) and Buspar (buspirone). However, KalmPro was formulated to be taken alone, not in combination with prescription medications. But if you and your doctor decide that adding KalmPro to your treatment is right for you, then you may find that you will need less of the prescription medications once you take KalmPro, and your doctor may even find that you may not need your prescription medications anymore when on KalmPro. Please follow-up with your doctor to see if adding KalmPro or switching to KalmPro is right for you.