The optimal dose of inositol is 1500mg daily. Taking 12 grams daily is overdosing on it. I have formulated a natural supplement for anxiety, called KalmPro. KalmPro contains therapeutic doses of inositol, passionflower, lavender, l-theanine, and lemon balm, all natural ingredients with research studies showing they are effective and safe for anxiety. Regarding your question about taking inositol with Paxil and Effexor, this question needs to be discussed with your prescribing doctor. From customers who bought KalmPro, the ones taking it with antidepressants report that they are able to decrease the dose of their prescription anxiety medication when taking KalmPro. Some have even switched to KalmPro from prescription medications without problems. But you do need to consult with your doctor before making any changes to your prescription medication regimen.